Bioidentical Hormone Replacement Therapy (BHRT)

Bioidentical Hormone therapy is administered to maintain hormonal balance to help with the symptoms of aging.
As men and women age, hormone production declines. Over our life time, we are exposed to environmental and dietary toxins, which contribute to the natural decline of hormones. This imbalance can affect people mentally, emotionally, physically, and can increase the risk of age-related illness, such as heart disease, osteoporosis, Alzheimer’s disease diabetes and certain cancers.
The goal of BHRT is to restore the body’s hormonal balance, in an effort to optimize health during the aging process. The benefits of natural hormone therapy include weight loss, increased energy, enhanced memory, improved sleep and libido.

Are Bioidentical Hormones safe?

The term “bioidentical” refers to a hormone with the same chemical structure as those naturally made by the body, and are metabolized by normal metabolic pathways.
Synthetic, or non-bioidentical hormones, are manufactured with a different chemical structure than those naturally produced by the human body. Studies have shown that synthetic HRT can significantly increase risk strokes, heart attacks, breast cancer, and blood clots.

REMEMBER: These studies were conducted using Synthetic Hormones. NOT Bioidentical Hormones.
Ex: Premarin – A synthetic estrogen medication isolated from the urine of pregnant mares with a mix of steroids and salts.

Bioidentical hormone therapy is safe and free of the risks associated with synthetic hormones.
Studies have shown the long term health benefits of Bioidentical Hormone optimization reduces the risk of the diseases associated with aging. (i.e. cancer, heart disease, osteoporosis, stroke and cognitive impairment).

Estrogen in the prevention of Atherosclerosis Trial

Menopause. 2005 July-Aug; 12 (4): 336-373

  • Fasting glucose, insulin and hemoglobin A1c were lowered and insulin sensitivity increased with estradiol therapy.
  • Unopposed 17Beta-estradiol reduced carotid intimal progression in postmenopausal women in party by increased HDL-cholesterol and lower decreasing LDL-cholesterol.

Androgen Deficiency in the Aging Male

Clinical Geriatrics, 2008 April: 25-28

  • Low testosterone levels in the aging male may contribute to the development of several comorbid conditions, such as myocardial infarction, coronary atherosclerosis, type 2 DM, obesity, hypertension and osteoporosis.

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive Heart Failure

American Journal of Cardiology. 1998 Feb 15; 81(4)443-447

  • Most patients with advanced congestive heart failure have altered thyroid hormone metabolism.
  • A low triiodothyronine (T3) level is associated with impaired hemodynamics and is an independent predictor of poor survival.

Subclinical Hypothyroidism is an independent risk factor for atherosclerosis and myocardial infraction in elderly women: The Rotterdam study

Ann Internal Med. 2000;132:270-278

  • Mild Thyroid disease is in the same ballpark as well-established cardiac risk factors like high cholesterol and smoking.
  • Subclinical hypothyroid is linked with a more-than-twofold increase in heart attack risk among women aged 55 and older.

Types of Bioidentical Hormones

  • Estrogen
  • Progesterone
  • Testosterone
  • DHEA
  • Thyroid
  • Melatonin
  • Pregnenolone

Testosterone

Testosterone is the principal steroid hormone found in both males and females. The testes produces testosterone in males, and the ovaries produce testosterone in females. Testosterone is notorious for its role in sexual function, but it also builds muscle mass, strength and endurance, decreases fat and maintains bone density. It is now well known that testosterone levels decrease with age beginning in the 30’s.

Symptoms of low testosterone include:

  • Fatigue
  • Depression
  • Poor skin tone
  • Decreased sexual performance and libido
  • Decreased muscle mass
  • Decreased bone density

With balanced testosterone levels, the following benefits can be experienced:

  • Enhance your mood and well-being
  • Improve sex drive
  • Improve energy
  • Improve muscle strength and growth
  • Improve skin and decrease wrinkles
  • Enhance bone density
  • Lower body fat
  • Lower blood pressure
  • Lower cholesterol levels

Estrogen

Contrary to popular belief, both women and men create estrogen. It is a break down product of testosterone and is also found in abdominal fat. In women, estrogen along with progesterone plays a critical role in sexual development, mood, ovulation, and lactation after pregnancy. In men, when levels are low or unbalanced, the risk of heart disease soars.

Low levels of Estrogen include:

  • Incontinence
  • Sagging skin and breasts
  • Increased wrinkles
  • Fatigue
  • Depression
  • Mood swings
  • Decreased libido secondary to vaginal atrophy

Benefits of optimizing Estrogen levels:

  • Protects against: Osteoporosis, Alzheimer’s disease, Heart Disease, Hot flashes, Strokes, Colon cancer, vaginal dryness/itching
  • Strengthens: Cardiovascular function, sex drive, muscle tone, and hair texture

Progesterone

Progesterone plays a role in maintaining pregnancy. The hormone is produced in the ovaries and placenta. It helps prepare the body for conception and pregnancy and regulates the monthly menstrual cycle. Estrogen and progesterone are synergistic hormones, helping to promote optimal female health.

Benefits of optimal Estrogen and Progesterone levels:

  • Reduces symptoms of PMS
  • Reduces symptoms of perimenopause and menopause
  • Improves bone growth
  • Protects against heart disease, and breast cancer

DHEA

DHEA (dehydroepiandrosterone) is a very powerful anti-oxidant that is produced from cholesterol. It is the primary building block to all other sex hormones: estrogen, testosterone, and progesterone. It is referred to as the “mother of all hormones.”

  • Improves: immune response, well-being, sex drive, emotional stability, memory, and cognitive function
  • Lowers: risk of cancer, coronary heart disease, and diabetes

Thyroid

Thyroid hormone is critical for almost every body function. It regulates metabolism, body temperature, nervous system, and menstrual cycles. Healthy levels have been known to protect against coronary vascular disease and cognitive impairment. In addition, thyroid hormone plays an important role in the integrity of skin, hair, and nails.

Improves symptoms of too little thyroid (hypothyroidism)

  • Weak, cold, tired, fatigued
  • Dry skin, thin hair, thin nails
  • Weight gain
  • Loss of motivation and energy
  • Poor sense of well-being and depression
  • Bowel function and constipation

Melatonin

Melatonin is a hormone found naturally in the body. It helps regulate other hormones and maintains the body’s circadian rhythm. It helps control the timing and release of female reproductive hormones. Melatonin possesses potent anti-oxidative effects and potential anti-cancer agent, because it is one of the best free radical scavengers in the body.

Benefits of optimal Melatonin therapy:

  • Improves Immunity
  • Better REM sleep
  • Lowers blood pressure
  • Decreases migraines
  • Powerful antioxidant

BHRT Treatment Plan

  1. Consult to discuss medical history and BHRT benefits
  2. Testing of hormones levels
  3. Follow-up to discuss hormone levels and BHRT treatment plan
  4. Hormone prescription and review of risks and benefits.
  5. One month follow-up and repeat hormone testing

If you have any of the above symptoms, call for an appointment to start optimizing your hormones and your health. We can schedule you a hormone evaluation.

Articles on Thyroid Hormone

  • “Long term thyroid replacement with high doses has no significant effect in bone density or fractures.” Lancet 1992 Jul 4; 340(8810):9-13.
  • “Combined thyroid therapy with T4 and high dose T3 resulted in improvement of symptoms and well being, whereas straight T4 did not. Not only did they feel better, but the patients taking both T4 and T3 also lost weight. The straight T4 did not.” Journal of Clinical Endocrine Metabolism 2005 May; 90(5):2666-74
  • “Over 40 studies prove that thyroid replacement does not lower bone density or cause increase risk of fracture.” Cortland Forum; 2001 July:85-89.
  • “Decreased T3 levels result in increased cholesterol and heart disease. Treating with T3 improves the lipid profile.” Preventive Cardiol 2001;4:179-182
    Low T3 levels are associated with increased heart disease and decreased cardiac function. Replacing T3 increases clinical performance and cardiac output. Adding T3 increases exercise tolerance and quality of life.” CVR & R 2002;23:20-26
  • “Low levels of free T3 in patients resulted in increased disability, depression, decreased cognition, and energy and increased mortality.” JAMA Dec. 2004; Vol. 292(2c): 500-504.
  • “Low normal thyroid levels result in increased cholesterol, increased heart disease, fatigue, low energy, depression, and memory loss. Thyroid replacement eliminates thee risks. No study has shown any harm or adverse effect of treatment.” Consultant 2000 Dec: 2397-2399.
  • “Long term thyroid replacement with high doses has no significant effect in bone density or fractures.” Lancet 1992 Jul 4; 340(8810):9-13.
  • Fibromyalgia is frequently seen in hypothyroidism. There is now evidence to support that fibromyalgia may be due to thyroid hormone resistance (cellular hypo-function).” Medical Hypotheses 2003 Aug;21(2):182-89.
  • “Combined T4 and T3 therapy resulted in improved symptoms, well-being and weight loss in comparison with straight T4 therapy. A decrease in weight resulted from using higher T3 levels.” J Clin Endocrinol Metab 2005 May;90(5):2666-74.
  • “Long term high doses of thyroid had no adverse effect in causing osteoporosis or fractures” Cortland Forum July 2001:85-90
  • “TSH is a good test to diagnose hypothyroidism. However TSH is a poor measure of symptoms of metabolic severity. It is, therefore, the biological effects of thyroid hormone on the peripheral tissue and not the TSH concentration, that reflects the clinical and metabolic effects.” British Medical Journal Feb 2003;Vol. 326:325-326.
  • “Even though the TSH is in the normal range, patients continue to have persistent symptoms despite adequate replacement doses. These patients are still symptomatic due to low T3 levels.” BMJ Feb. 2003; Vol 326:295-296.
  • “Patients that took a combination of T4 and T3 experienced better mood, energy, concentration and memory and improved well-being. Patients on just T4 experienced no change.” New England Journal of Medicine Feb. 1999;340:424-9
  • “Women with low normal thyroid levels had a 4-fold increase risk of heart disease. This increased risk was equal to the risk of smoking and high cholesterol. Low normal thyroid levels are a strong predictor for heart attacks.” Annals of Internal Medicine 2000; 132: 270-278.

Article for Testosterone

  • “Loss of testosterone causes loss of libido, energy, strength, sexual function, memory, cognition, muscle and bone. Testosterone replacement, as far as quality of life is concerned, is tremendous.” Medical Crossfire 2001Jan;Vol.3 No.1:17-18
  • “Symptoms of low testosterone may occur due to decreased serum levels or reduced receptor site sensitivity. In spite of normal blood levels patients will still feel and function better when testosterone is prescribed.” Medical Crossfire 2001 Jan;Vol.3 No. 1:17-18.
  • “Testosterone replacement improves muscle mass and strength, libido, erectile function, bone density, memory, cognition, myocardial function. It is unconscionable for physicians not to treat men with testosterone.” Medical Crossfire 2001Jan;Vol. 3 No.1:47-50.
  • “Low testosterone levels are associated with an increased risk of diabetes, heart disease, and carotid atherosclerosis.” Diabetes Care 2003 June;Vol. 36, No. 6: 20-30.
  • “Testosterone levels have nothing to do with causing prostate cancer.” Cancer 1999, July 15;88(2):312-5.
  • “None of the 12 longitudinal population based studies, such as the “Physician’s Health Study,” found any increased risk of prostate cancer in men with higher levels compared to men with lower levels of testosterone.” New England Journal of Medicine 2004;350:482-92.
  • “Low testosterone levels increase cardiovascular disease. High testosterone levels protect against cardiovascular disease.” Diabetes Metab 1995 Vol. 21:156-16
  • “Testosterone replacement in women significantly decreases carotid atherosclerosis and cardiovascular disease.” American Journal of Epidemiology 2002;155: 437-445
  • “Administration of testosterone to women eliminates hot flashes, lethargy, depression, incontinence, fibrocystic disease, migraine headaches, and poor libido. Testosterone also improves well-being, sexual desire, frequency and intensity of orgasm.” Consultant; 1999 August: 2006-07.
  • “Higher testosterone levels increase cognition and memory.” Neurology 2005 Mar. 8; 64-5:866-71.
  • “Testosterone decreases cholesterol and raises HDL.” Atherosclerosis 1996 Mar;121(1): 35-43.
  • “Low testosterone levels are associated with higher cardiovascular risk. Testosterone supplementation reduces abdominal fat and improves insulin sensitivity. Testosterone lowers cholesterol also.” Diabetes Metab 2004 Feb;30(1):29-34
  • “Hormone replacement therapy in postmenopausal women and testosterone replacement in men reduce the degree of central obesity.” Obesity Review 2004 Nov; 5(4): 197-216.
  • “High doses of synthetic, anabolic steroids cause side effects. No such side effects have been observed using low doses of natural testosterone. Avoidance of supraphysiologic levels prevents any side effects.” Female Patient 2004 Nov; Vol.29: 40-45.
  • “Testosterone increases bone density in women. Testosterone protects against heart disease in women.” Journal of Reproductive Medicine 1999; 44(12):1012-20
  • “Low DHT (dihydrotestosterone) predicted a higher rate of cancer. Higher DHT levels were associated with a lower risk of cancer”. Brit.J.Urol 1990 Mar;77(3)443-37.

Articles on Melatonin

  • “Melatonin has been shown to slow the growth of some cancer, prevent some cancer and decreases side-effects of many chemotherapeutic agents.” Medical Hypothesis 1997 June; 49(6):523-35.
    (Melatonin has become so popular that there is now a synthetic, chemically altered melatonin made by a pharmaceutical company to treat insomnia.)
  • “Use of melatonin in elderly patients with insomnia demonstrated improvement in sleep quality. This study is consistent with other studies.” Patient Care 2000 June:34-38.
  • “In this study patients were successfully weaned from benzodiazepines (valium), with the sleep regulating hormone melatonin: Melatonin was not associated with adverse effects or tolerance.” Archive of Internal Medicine; 1999 Nov 159: 2456-2460.
  • “Melatonin possesses strong antioxidant properties with increases in brain glutathione. Melatonin possesses potent anticancer effects, increases and improves immune defenses, inhibits tumor growth factor production.” Journal Pineal Research 1999 Aug ;23(i): 15-19.
  • “Night time administration of melatonin relieves migraine headaches.” Neurology 2004 August; 246-250.

Articles on progesterone:

  • “The main reason women discontinue HRT is due to side effects. Synthetic progestin’s (Provera®) cause may side effects: breast swelling and tenderness, uterine bleeding, depression and mood disturbance, weight gain, bloating and edema. Natural progesterone has no side effects.” Female Patient 2001 Oct; 19-23.
  • “Progesterone should be administered to all women, hysterectomy or not.” Infertility and Reproductive Medicine Clinics of North America; 1995 Oct;Vol.6(4):653-673.
  • “Due to the side effects of synthetic progestin’s, natural progesterone is preferred. Progesterone has proven bio-availability and no side effects making it the preferred hormone for menopause.” American Family Physicians 2000;62: 1339-46
  • “Estrogen and progesterone are neuro-protective against cerebral damage. These beneficial effects were blocked by MPA (medroxyprogesterone).” National Academy Science USA; 2003 Sept. 2;100(8):10506-11.
  • “Natural estrogen and natural progesterone offer substantial clinical benefit over the synthetic hormones and should be the agents of choice for menopause.” Obstetrics Gynecology 1989;73:606.
  • “The estrogen only arm of the WHI Trial demonstrated no increased risk of breast cancer with estrogen. This study therefore demonstrates that the breast cancer increase was due to medroxyprogesterone (Provera®) and not due to estrogen.” Family Practice News 2004 March 15;1-3.
  • “Progesterone reduces proliferation of breast cancer cells and induces cellular apoptosis (kills breast cancer cells) Maturitas 2003 Dec;46(1):555-58
  • “Due to the side effects of synthetic progestin’s, natural progesterone is preferred. Progesterone has proven bioavailability and no side effects making it the preferred hormone for menopause.” American Family Physician 2000; 62:1939-46
  • “Progesterone raises good HDL cholesterol, whereas MPA (Provera®), lowers good cholesterol. Progesterone increases estrogen beneficial effects whereas MPA reverses estrogen’s benefits. Progesterone has no side effects, whereas MPA has many” Obstetrics Gynecology 1989;73:606-611.
  • “Progesterone decreases Breast stimulation 400%, and down regulates breast receptor sites, thereby protecting against breast stimulation.”Fertility Sterility 1998;69:963-69.
  • “Mammary tumor stimulation was reduced both by progesterone and Tamoxifen, more so by progesterone by Tamoxifen which is the drug of choice to treat cancer.” Japan Journal of Cancer Research 1985June;76:699-04.