Neural Prolotherapy

What is Neural Prolotherapy (NPT)

nerve1Neural Prolotherapy is an exciting new treatment in the world of regenerative orthopedic medicine. It is a treatment for pain, which uses shallow injections of a 50% dextrose (sugar) solution into the surrounding area of an inflamed peripheral nerve. The goal is to reduce the neurogenic inflammation, swelling and pain.

Dr. John Lyflogt expanded on the treatments that were introduced in 1989. He has been using this technique to treat various pain conditions and musculoskeletal conditions over the last decade with outstanding results.

The theory of NPT was based on “Hilton’s Law”, named after Dr. John Hilton, a British surgeon. He stated that the nerve that innervates a joint also innervates the skin overlying that joint and the muscles that move the joint. Dr. Lyflogt found that an irritated nerve that supplies sensation to the skin over a joint may also cause dysfunction and pain to the muscles and tissue around that joint. Dr. Lyflogt theorized that restoration of peripheral nerve function would lead to healing in deeper structures and a reduction in pain. NPT is now being taught around the world.

How does Neural Prolotherapy work?

When tissue is injured, the body releases its own pro-inflammatory substances (Brandykinin, Prostaglandins) that stimulate a channel on nerves called “transient receptor potential V1” (TrpV1), also known as the cupsacin receptor. When the channel is turned on, the nerve releases inflammatory chemicals (substance P and Calcitonin gene related peptide (CGRP), causing swelling and pain. It is theorized that Dextrose, the active ingredient in NPT, turns off TrpV1, preventing the release of the inflammatory substance and restoring nerve function.

What is the solution injected?

50% Dextrose in normal saline and Sodium Bicarbonate

Are the treatments painful and are they safe?

The injections are shallow, so the pain is minimal. NPT is safe when given by a trained practitioner. Dextrose is something we consume daily in our diets, and the injection is just beneath the skin.

How will I feel after the injections?

Patients will often have immediate relief. Depending on the severity of the pain, some may require multiple treatments to reduce their pain. Bruising at the injection sites is common. Treatments are given 2-4 weeks apart.

What conditions can be treated with NPT?

  • Back pain
  • Foot/ankle pain
  • Shoulder pain
  • Wrist/hand pain
  • Neck pain
  • Knee pain
  • Achilles tendonitis